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Researchers at University College London proved that smoking during pregnancy can cause deformations, such as cleft lip and cleft palate, as early as when an embryo transforms in the third week of pregnancy

There are treatments that can help reduce or eliminate vertical lines around the mouth

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Long-term health risks of vaping are still being studied but include potential risks to cardiovascular and respiratory health, including the possibility of chronic obstructive pulmonary disease (COPD) and asthma