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This action leads to depolarization, which triggers voltage-gated calcium channels and promotes calcium passage to the axon terminal

Texture Changes Properly conditioned tobacco should feel slightly springy and pliable

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This addiction can result in severe psychological distress, including anxiety, paranoia, and depression

Accessed 10 Nov 2025 Karelitz JL, He Y, Becker E, Vansickel A (2025) Switching behavior and changes in smoking behavior by menthol cigarette preference and menthol heated tobacco product use among adults in the United States who smoke cigarettes: an actual use study