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In conclusion, the functional characteristics of CSE-exposed CCR6 + Th17 cells, both inflammatory and angiogenic, could contribute to the pathogenic potential of cigarette smoking in susceptible patients, as described for circulating angiogenic T cells in encephalomyelitis, systemic lupus erythematosus, systemic sclerosis and rheumatoid arthritis 38,39

Recent research highlights the benefits of vitamin D3 in modulating immune responses and reducing inflammation [29]