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Available first line treatment options include nicotine replacement therapy (NRT), varenicline, and bupropion

The pipes' fragility eventually led to its decline so that by the nineteenth-century pipes were being replaced by cigars and cigarettes as preferred methods of intake, though eventually more hardy pipes also would be created

Patients usually interpret some symptoms as adverse events due to treatment, instead of symptoms related to smoking cessation

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Technologies like genome-wide association studies (GWAS) and genomic selection (GS) can be applied to identify quantitative trait loci (QTLs) associated with stress resistance and use them in marker-assisted breeding ( Conclusion and future perspectives High temperatures and drought represent significant environmental stressors that profoundly influence the growth and development of tobacco plants