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The production is one of the largest sources of income for the Indonesian government and the production, which is spread out among some 500 independent manufacturers, employs some 180,000 people directly and over 10 million indirectly
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Inhaled cigarette smoke first encounters the airway epithelium, where it may induce oxidative stress by both acute effects of its reactive components and by the intracellular generation of endogenous reactive oxygen species (ROS) by mitochondria [16]
