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Briefly, the smoke of a 3R4F Research Cigarette (University of Kentucky, USA) was bubbled into a flask containing 10 mL of warm (37 C) RPMI-1640 medium by use of a vacuum pump at a constant speed

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Grabski M, Curran HV, Nutt DJ, Husbands SM, Freeman TP, Fluharty M, et al

This prompted them to split the company but keep the Aldi name