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Li KJ, Chen ZL, Huang Y, Zhang R, Luan XQ, Lei TT, et al

Consider follow-up actions : Depending on the context, consider recommending follow-up actions based on the individual's score

Put the situation into perspective and dissect it to its minutiae, until you can make sense of your fears

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MR is based on three key assumptions: 1) the genetic variants used as instruments for the exposure must be valid and robustly associated with the exposure, 2) there should be no measured or unmeasured confounding of the association between the genetic instrument and the outcome, and 3) the variants should have no independent effect on the outcome other than through the exposure of interest 17