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One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30

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Urinary cotinine levels are elevated in infants of smoking mothers

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Less Smoking Heavy smokers agreed that by shifting to roll-ups, they automatically came to smoke less

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