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Such variance in smoking liability in the remaining sample of baseline never smokers could potentially influence e-cigarette use and thus confound associations between e-cigarette use and later transition to ever smoking

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In the non-psychiatric cohort, CHANTIX was not associated with an increased incidence of clinically significant neuropsychiatric adverse events in a composite endpoint comprising anxiety, depression, feeling abnormal, hostility, agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, and irritability

Jackson SE, Tattan-Birch H, Buss V, Shahab L, and Brown J

Vasc Health Risk Manag

And that, of course, can raise your risk of heart attack or stroke