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Toxicity and hepatocarcinogenicity may occur when liver responses exceed adaptive changes or induced enzymes generate toxic metabolites (Table 5.5)
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The UK has become the second country in the world and the first in Europe to require cigarettes to be sold in plain standardised packaging although there is a grace period of one year to allow manufacturers and retailers to use up current stock
Irene Ryan: chain-smoker, died 1973, brain tumor, aged 70 Buddy Ebsen: unknown, died 2003, pneumonia, aged 95 Dick Van Dyke: former smoker, alive, aged 84 Rose Marie: smoker or former smoker, alive, aged 86 Lucille Ball: chain-smoker, died 1989, aortic aneurysm, aged 77 Desi Arnaz, Sr.: chain-smoker, died 1986, lung cancer, aged 69 Steve McQueen: former smoker, died 1980, mesothelioma, aged 50 John Wayne: former chain-smoker, died 1979, lung/stomach cancer, aged 72 Johnny Carson: chain-smoker, died 2005, respiratory arrest arising from emphysema, aged 79 Last word goes to John Wayne
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