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Cells were processed through hypotonic treatment (0.075 M KCl) and fixation with methanol:acetic acid (3:1)

Mendelian randomisation (MR) analysis In the present study, a modified Mendelian randomisation approach was performed to investigate a potential causal relationship 36,65 , in which non-pleiotropic polygenic risk scores (i.e., the valid-PRS) were established as instrument variables of randomised experiments for potential causal inference

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