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Some common barriers to quitting include stress, weight gain, and the presence of smoking peers

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The healthy group consisted of 16 smokeless-tobacco-consuming (TC-H) and 16 non-consuming individuals (NTC-H) with age between 21 and 60 years (32.15 9.19, mean Stdev), whereas 24 OSCC patients were smokeless tobacco consumers (TC-OSCC), and 10 were non-consumers (NTC-OSCC) with age ranged between 23 and 75 years (48.61 12.76, mean Stdev) ( Figures 1A, B

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