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Barua et al., using this model (40, 41) found that by modifying the endotheliums NO synthase enzymes expression and activity, exposure to smokers sera reduced the availability of NO from human coronary artery endothelial cells (HCAEC) and HUVECs

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Since we are using ITT, all participants randomized to a treatment arm will be included in the analysis so our n will remain constant and our power to detect a difference between groups should not be significantly affected by loss to follow-up as long as it is more or less equal in the two arms

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Whilst theres no specific law that says you cannot smoke and drive, the key issue is whether smoking or vaping affects your ability to drive safely