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Do not use if you continue to smoke, chew tobacco, use snuff, use nicotine gum, or use another nicotine patch or other nicotine containing products Ask a doctor before use if you have heart disease, recent heart attack, or irregular heartbeat

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However, despite its protective role, the constant activation of the Nfr2 pathway in response to e-cigarette use, particularly the flavouring agents found in e-cigarettes, can exhaust this protective pathway, leading to eventual cellular death in the epithelium (Ma et al

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