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As noted above, PET studies similar to this one demonstrated that PLWH have elevated levels of the PET marker for neuroinflammation and higher levels of the marker are associated with worse cognitive impairments [19, 21]

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Persistent mitochondrial damage in airway epithelium of COPD patients is further evidenced by the increased expression of PINK1, a sensor for damaged mitochondria, and PPARGC1, a regulator of mitochondrial biogenesis [20, 46]

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