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Glutamatergic inputs from the pedunculopontine tegmental nucleus to midbrain dopaminergic neurons in primates: Phaseolus vulgaris -leucoagglutinin anterograde labeling combined with post embedding glutamate and GABA immunohistochemistry

While about half of baseline smokers (87/181) had only once or twice experience of smoking before the baseline interview, most of them (166/181) did continue and report increased smoking frequency at the follow-up interview (Table 1)

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In the brain, limbic pathways that use the neurotransmitter dopamine are affected by nicotine and may be responsible for some of the addictive properties

The OHS is not risk free and contains nicotine, which is addictive

European Journal of Cancer