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The clinical significance of vascular endothelial function has become clear in many aspects such as understanding the etiology, pathogenesis, involvement in the development of atherosclerosis, therapeutic targets, and prognostic factors

Although smoke has been shown to cause apoptosis of HBE cells 5,6,7 , apoptosis is classically considered a non-inflammatory form of programmed cell death 8

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While this assumption is both plausible and supported by research on either ends (disadvantage leads to higher levels of daily stress [19]

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Addiction is considered to exist when the user continues to use the drug regularly despite behavioral, cognitive, perceptual, and emotionally negative symptoms