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Cigarettes contain over 7,000 chemicals, including tar and carbon monoxide, which cause lung damage

Excessive oxidative stress may induce oxidative modifications, including peroxidation of mitochondrial lipids, oxidative damage of mitochondrial proteins including OXPHOS components, cristae remodeling, mutations and severe damage in mitochondrial DNA (mtDNA) [5, 6, 22, 39, 40, 42, 43]

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All findings for cotinine were similar for 3OH-cotinine

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His cover of the Box Tops The Letter another fairly significant reimagining of an existing hit was his first Billboard top 10 in the U.S