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Authors contributions JD participated in the conception of the literature review and paper, reviewed published studies, analyzed data, and drafted portions of the manuscript

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E-cigarette devices range in size and appearance: from disposable devices that look like a plastic cigarette, large tank devices that contain a refillable vessel and large batteries, to devices that resemble USB drives (known as Juul pods)

Surgeon General , CDC , FDA , AMA, World Health Organization , and the National Institute on Drug Abuse , classifies nicotine as the primary addictive compound in tobacco products.[7] Clinical reports have documented patients who, despite never smoking, developed severe dependence on nicotine gum

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