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Trans-3-hydroxy-cotinine and cigarettes per day including loess fit curve with 95% confidence interval in ( A ) men (smoothing parameter 0.94) and ( B ) women (smoothing parameter 0.86)

Data availability The datasets generated during and/or analyzed during the current study are available at the website of Global Health Data Exchange (GHDx) ( healthdata

Its recommended to initially start with a higher nicotine strength e-liquid and then gradually reduce the strength

They also provide further support for emphasizing the social consequences of smoking

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