Similarly, individuals at an increased risk of developing GERD are tobacco smokers, have excess weight and consume alcohol, in addition to other dietary factors
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10.1007/s00204-012-0884-5
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As the issue advanced in longevity during its distribution, its content expanded to accommodate fans (and smokers) living outside relatively few major league cities during that time
For one thing, Up is about people with no superpowers, nor are the characters anthropomorphized animals or toysremember, the dogs in Up can only speak due to super-science and still pretty much act like dogs