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Firstly, the detection bias may be due to the low participation rate of smokers in PSA screening, especially in areas with limited opportunities for routine testing, which may underestimate the incidence rate of PCa and delay the diagnosis of invasive diseases

While coffee is the most common of the types of teeth stains, there are also tea and wine teeth stains

A 2023 updated Cochrane SR confirmed efficacy of bupropion for tobacco smoking cessation (and less so, nortriptyline), but it found no evidence in favour of SSRIs or venlafaxine

Nevertheless, smoking has not fallen nearly as quickly as taxes have risen