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The rate for males was 12.7/100000, and there was no significant difference between males and females 17

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Over time, the brain adapts by: Reducing natural dopamine production Requiring higher doses of nicotine to feel the same effects Increasing cravings and irritability without nicotine The National Institute on Drug Abuse (NIDA) reports that nicotine produces addiction-related brain changes comparable to other highly addictive substances, helping explain why quitting can feel difficult even after relatively short-term use