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When nicotine enters the body, it binds to neurotransmitter receptors in the brain called nicotinic acetylcholine receptors (nAChRs) that in turn bind to the neurotransmitter acetylcholine (ACh)

Studies show THC and other plant cannabinoids are metabolized in the body by cytochrome P450 enzymes (mainly CYP3A4 and CYP2C9)

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The chronic WCSE model, combined with human lung organoids, captures the essential features of this transition, bridging the gap between acute in vitro assays and long-term pathological remodeling